Therapeutics of vitamin D 12.12.2022

Introduction

• The central role of vitamin D in bone health is well recognized.
• We aimed to review the definition of hypovitaminosis D, the skeletal and extra-skeletal effects of vitamin D and the available therapeutic modalities.

Questions relating to areas of agreement

• Is vitamin D3 superior to D2? – Pharmacokinetics, clinical data.
• What is the role for 25-hydroxyvitamin D in replacement and its availability?
•  Is there a place for active vitamin D metabolites in treating vitamin deficiency?
•  Is daily dosing of vitamin D preferred to larger weekly, monthly or annual doses?
•  Does the baseline level of serum 25-hydroxyvitamin D influence the choice and frequency of dose?
•  Does BMI or race influence the dose or mode of administration?
•  What is the role of fortification in increasing vitamin D?
•  How much is too much vitamin D? • What adverse outcomes are important?